Endocrine Abstracts

Background: Septo-optic dysplasia (SOD) is a rare congenital condition diagnosed in children with two or more of hypothalamo-pituitary axis dysfunction, midline brain abnormalities, and optic nerve hypoplasia. SOD has a heterogenous clinical phenotype, characterised by varying visual impairment and endocrine dysfunction. Autistic-like behaviours have also been reported in children with SOD, however the nature of these neurobehavioural impairments remain to be fully understood....

Background: Craniopharyngioma is a benign tumour involving the hypothalamic and pituitary regions that are involved in the production and secretion of oxytocin. Research has shown that dysfunction of the oxytocin system is associated with neurobehavioural and metabolic outcomes, but less is known for its role in patients with craniopharyngioma, largely due to varied study designs and heterogenous methods of assessing the oxytocin system. This systematic review...

Aims: End stage renal disease is associated with disorders of calcium and phosphate metabolism that favor the loss of bone mass.Kidney transplant may alter this unbalance restoring bone mass. Nevertheless, recent studies showed that 48 months after transplant, the loss of bone mass still is superior to general population. Post-transplant corticosteroid therapy is considered the main responsible for the loss of bone mass.The authors...